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High-resolution cryo-electron microscopy (cryo-EM) has successfully elucidated the exact spatial orientation and the precise residue-by-residue thermodynamic interactions that permit this unimolecular polypharmacology

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doi: 10.1016/j.expneurol.2013.10.002 89

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Consequently, the failure of T-cell infiltration, which results from the multitiered barriers imposed by tumors, serves as a foundational and broadly adaptive resistance mechanism that directly impedes the clinical outcomes of multiple T-cell-centric immunotherapies

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Pro-apoptotic signaling of JNK1 is mediated by the upstream MAP3K apoptosis signal-regulating kinase (ASK1) cascade (147)

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